Cancer remains one of the most complex diagnoses due to its ability to spread through internal organs. A particular difficulty is abdominal carcinomatosis, where tumor nodes localize on the peritoneum, complicating traditional surgery. To combat such aggressive forms of the disease, Booking Health offers access to innovative technologies that go beyond traditional medicine. Today, patients have a chance to stabilize the condition even when systemic therapy ceases to bring the expected result.
What is PIPAC technology and its role in oncology?
PIPAC – is a minimally invasive method of locally injecting chemotherapy drugs directly into the abdominal cavity as a fine-dispersed aerosol. Unlike traditional intravenous therapy, pressurized aerosol penetrates deeper into tumor tissues, ensuring maximum concentration of the active substance with minimal side effects. This approach was a real breakthrough for patients who need an effective PIPAC cancer treatment. Booking Health helps organize such treatment in specialized centers that use state-of-the-art drug spraying equipment.
Due to the tightness of the system and controlled pressure, drugs are administered evenly over the entire surface of the peritoneum. This provides inhibition of the growth of microscopic metastases, which are difficult to affect by standard methods. aroscopic access.
What are peritoneal carcinomatosis symptoms?
Peritoneal carcinomatosis – is the spread of cancer to the peritoneum – the thin membrane that lines the abdominal cavity and covers most of the abdominal organs.
The symptom picture in peritoneal carcinomatosis is broad and variable. It is driven more by the extent and anatomical location of disease than by the primary tumor type.
Abdominal symptoms are the most prominent:
- abdominal pain;
- abdominal distension;
- nausea and vomiting;
- malignant ascites (fluid build-up in the peritoneal cavity).
Gastrointestinal and systemic symptoms:
- malignant bowel obstruction;
- constipation or diarrhea;
- fatigue;
- cachexia and weight loss.
It is important to know that peritoneal carcinomatosis can be silent for a considerable period.
PIPAC peritoneal carcinomatosis: what is the procedure mechanism?
For some patients, PIPAC procedure is often the only chance to stop the progression of the disease when major surgery is not possible due to health reasons. Booking Health emphasizes that the technique allows not only to prolong life, but also to significantly improve its quality, reducing pain syndrome.
The procedure is performed laparoscopically under general anaesthesia, typically taking about 45-60 minutes. It can often be done as a short-stay procedure. Laparoscopic access is established using the open (Hasson) technique. Two balloon trocars are inserted in the abdomen. CO₂ is insufflated to create a capnoperitoneum (pneumoperitoneum). The pressure is 12 mmHg and the temperature is 37°C (normothermic, unlike HIPEC). The chemotherapy solution is aerosolized into the abdominal cavity under pressure and is maintained for 30 minutes. Then the aerosol is evacuated through a closed suction system.
Why do patients choose PIPAC treatment abroad through Booking Health?
The PIPAC treatment Germany program is famous for the fact that it was German scientists led by Professor Marc André Reymond who developed and implemented this technique. Germany remains the main scientific hub where new generations of this procedure are performed. Booking Health provides patients with direct access to these innovations, guaranteeing support throughout the treatment period and even after that.
In addition to technical excellence, German clinics offer a multidisciplinary approach, combining aerosol chemotherapy with systemic treatment. This significantly increases the chances of stabilizing the condition even in the late stages of the disease. Below is a comparison of traditional chemotherapy and the PIPAC procedure:
Systemic chemotherapy vs PIPAC procedure
| Criteria | Systemic chemotherapy | PIPAC |
| Method of administration | Intravenously | Fine-dispersed aerosol |
| Tumor penetration | Limited due to tissues barriers | Deep (due to physical pressure) |
| Side effects | Systemic (nausea, hair loss) | Mild (abdominal pain, temporary inflammation) |
| Repeat intervals | Depends on general condition | Can be repeated every 6-8 weeks |
| Purpose | Handling extraperitoneal disease | Targeting the peritoneal compartment |
